Molecular signatures of G-protein-coupled receptors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature11896.pdf
Reference100 articles.
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2. Tate, C. G., Schertler, G. F. & Engineering, G. Protein-coupled receptors to facilitate their structure determination. Curr. Opin. Struct. Biol. 19, 386–395 (2009)
3. Cherezov, V. et al. High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor. Science 318, 1258–1265 (2007)
4. Rosenbaum, D. M. et al. GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318, 1266–1273 (2007)Description of the T4 lysozyme fusion strategy that led to the first high-resolution β 2 -AR structure using the lipidic cubic phase crystallization technique3, which has been subsequently used to facilitate the crystallization of many other GPCRs.
5. Thompson, A. A. et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature 485, 395–399 (2012)
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