Universal DNA methylation age across mammalian tissues-Reference-Cited by-同舟云学术

Universal DNA methylation age across mammalian tissues

Published:2023-08-10 Issue:9 Volume:3 Page:1144-1166
ISSN:2662-8465
Container-title:Nature Aging
language:en
Short-container-title:Nat Aging

Author:

Lu A. T.^ORCID,Fei Z.,Haghani A.^ORCID,Robeck T. R.,Zoller J. A.^ORCID,Li C. Z.^ORCID,Lowe R.,Yan Q.,Zhang J.^ORCID,Vu H.,Ablaeva J.,Acosta-Rodriguez V. A.^ORCID,Adams D. M.^ORCID,Almunia J.^ORCID,Aloysius A.^ORCID,Ardehali R.,Arneson A.,Baker C. S.^ORCID,Banks G.,Belov K.,Bennett N. C.,Black P.,Blumstein D. T.^ORCID,Bors E. K.,Breeze C. E.^ORCID,Brooke R. T.,Brown J. L.,Carter G. G.,Caulton A.,Cavin J. M.,Chakrabarti L.,Chatzistamou I.,Chen H.,Cheng K.,Chiavellini P.,Choi O. W.,Clarke S. M.^ORCID,Cooper L. N.^ORCID,Cossette M. L.^ORCID,Day J.^ORCID,DeYoung J.,DiRocco S.,Dold C.,Ehmke E. E.,Emmons C. K.^ORCID,Emmrich S.^ORCID,Erbay E.,Erlacher-Reid C.,Faulkes C. G.^ORCID,Ferguson S. H.^ORCID,Finno C. J.,Flower J. E.,Gaillard J. M.,Garde E.,Gerber L.,Gladyshev V. N.^ORCID,Gorbunova V.^ORCID,Goya R. G.^ORCID,Grant M. J.,Green C. B.,Hales E. N.,Hanson M. B.,Hart D. W.^ORCID,Haulena M.,Herrick K.,Hogan A. N.,Hogg C. J.^ORCID,Hore T. A.^ORCID,Huang T.^ORCID,Izpisua Belmonte J. C.,Jasinska A. J.^ORCID,Jones G.^ORCID,Jourdain E.,Kashpur O.,Katcher H.,Katsumata E.,Kaza V.,Kiaris H.^ORCID,Kobor M. S.,Kordowitzki P.^ORCID,Koski W. R.^ORCID,Krützen M.^ORCID,Kwon S. B.,Larison B.,Lee S. G.,Lehmann M.,Lemaitre J. F.^ORCID,Levine A. J.,Li C.,Li X.,Lim A. R.,Lin D. T. S.,Lindemann D. M.,Little T. J.,Macoretta N.,Maddox D.,Matkin C. O.,Mattison J. A.,McClure M.,Mergl J.,Meudt J. J.,Montano G. A.,Mozhui K.^ORCID,Munshi-South J.,Naderi A.^ORCID,Nagy M.^ORCID,Narayan P.^ORCID,Nathanielsz P. W.,Nguyen N. B.,Niehrs C.,O’Brien J. K.,O’Tierney Ginn P.^ORCID,Odom D. T.,Ophir A. G.^ORCID,Osborn S.,Ostrander E. A.^ORCID,Parsons K. M.,Paul K. C.,Pellegrini M.,Peters K. J.^ORCID,Pedersen A. B.,Petersen J. L.^ORCID,Pietersen D. W.^ORCID,Pinho G. M.^ORCID,Plassais J.^ORCID,Poganik J. R.^ORCID,Prado N. A.,Reddy P.,Rey B.^ORCID,Ritz B. R.^ORCID,Robbins J.^ORCID,Rodriguez M.,Russell J.^ORCID,Rydkina E.,Sailer L. L.^ORCID,Salmon A. B.^ORCID,Sanghavi A.^ORCID,Schachtschneider K. M.,Schmitt D.^ORCID,Schmitt T.,Schomacher L.^ORCID,Schook L. B.^ORCID,Sears K. E.^ORCID,Seifert A. W.,Seluanov A.^ORCID,Shafer A. B. A.,Shanmuganayagam D.^ORCID,Shindyapina A. V.,Simmons M.,Singh K.,Sinha I.,Slone J.,Snell R. G.^ORCID,Soltanmaohammadi E.,Spangler M. L.^ORCID,Spriggs M. C.,Staggs L.,Stedman N.,Steinman K. J.,Stewart D. T.,Sugrue V. J.,Szladovits B.^ORCID,Takahashi J. S.^ORCID,Takasugi M.,Teeling E. C.^ORCID,Thompson M. J.^ORCID,Van Bonn B.,Vernes S. C.,Villar D.^ORCID,Vinters H. V.,Wallingford M. C.,Wang N.,Wayne R. K.,Wilkinson G. S.^ORCID,Williams C. K.,Williams R. W.,Yang X. W.^ORCID,Yao M.,Young B. G.^ORCID,Zhang B.,Zhang Z.,Zhao P.^ORCID,Zhao Y.,Zhou W.,Zimmermann J.^ORCID,Ernst J.^ORCID,Raj K.^ORCID,Horvath S.^ORCID

Abstract

AbstractAging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.

Funder

Paul G. Allen Family Foundation

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Open Philanthropy/Silicon Valley Fund

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Geriatrics and Gerontology,Aging

Link

https://www.nature.com/articles/s43587-023-00462-6.pdf

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