Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Author:

Amor CorinaORCID,Fernández-Maestre Inés,Chowdhury Saria,Ho Yu-Jui,Nadella SandeepORCID,Graham CourtenayORCID,Carrasco Sebastian E.,Nnuji-John Emmanuella,Feucht Judith,Hinterleitner Clemens,Barthet Valentin J. A.ORCID,Boyer Jacob A.,Mezzadra Riccardo,Wereski Matthew G.,Tuveson David A.,Levine Ross L.ORCID,Jones Lee W.,Sadelain MichelORCID,Lowe Scott W.

Abstract

AbstractSenescent cells, which accumulate in organisms over time, contribute to age-related tissue decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies, including metabolic dysfunction and decreased physical fitness. While small-molecule drugs that eliminate senescent cells (‘senolytics’) partially replicate these phenotypes, they require continuous administration. We have developed a senolytic therapy based on chimeric antigen receptor (CAR) T cells targeting the senescence-associated protein urokinase plasminogen activator receptor (uPAR), and we previously showed these can safely eliminate senescent cells in young animals. We now show that uPAR-positive senescent cells accumulate during aging and that they can be safely targeted with senolytic CAR T cells. Treatment with anti-uPAR CAR T cells improves exercise capacity in physiological aging, and it ameliorates metabolic dysfunction (for example, improving glucose tolerance) in aged mice and in mice on a high-fat diet. Importantly, a single administration of these senolytic CAR T cells is sufficient to achieve long-term therapeutic and preventive effects.

Publisher

Springer Science and Business Media LLC

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