Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Author:

Doitsh Gilad,Galloway Nicole L. K.,Geng Xin,Yang Zhiyuan,Monroe Kathryn M.,Zepeda Orlando,Hunt Peter W.,Hatano Hiroyu,Sowinski Stefanie,Muñoz-Arias Isa,Greene Warner C.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference69 articles.

1. Thomas, C. Roadblocks in HIV research: five questions. Nature Med. 15, 855–859 (2009)

2. Muro-Cacho, C. A., Pantaleo, G. & Fauci, A. S. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J. Immunol. 154, 5555–5566 (1995)

3. Finkel, T. H. et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med. 1, 129–134 (1995)

4. Huang, M. B., James, C. O., Powell, M. D. & Bond, V. C. Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice. Ethnic. Dis. 18, S2–30–37 (2008)

5. Røsok, B. I. et al. Correlates of apoptosis of CD4+ and CD8+ T cells in tonsillar tissue in HIV type 1 infection. AIDS Res. Hum. Retroviruses 14, 1635–1643 (1998)

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