Exploring protein fitness landscapes by directed evolution
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2805.pdf
Reference112 articles.
1. Chen, K. & Arnold, F. H. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proc. Natl Acad. Sci. USA 90, 5618–5622 (1993). The first demonstration of directed evolution by successive rounds of mutagenesis and screening — a strategy now widely used to engineer enzymes.
2. Reetz, M. T. Combinatorial and evolution-based methods in the creation of enantioselective catalysts. Angew. Chem. Int. Ed. Engl. 40, 284–310 (2001).
3. Boder, E. T., Midelfort, K. S. & Wittrup, K. D. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. Proc. Natl Acad. Sci. USA 97, 10701–10705 (2000).
4. Campbell, R. E. et al. A monomeric red fluorescent protein. Proc. Natl Acad. Sci. USA 99, 7877–7882 (2002).
5. Jiang, L. et al. De novo computational design of retro-aldol enzymes. Science 319, 1387–1391 (2008).
Cited by 843 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering;ACS Central Science;2024-02-05
2. Addressing data scarcity in protein fitness landscape analysis: A study on semi-supervised and deep transfer learning techniques;Information Fusion;2024-02
3. The Effects of Buffer Nature on Immobilized Lipase Stability Depend on Enzyme Support Loading;Catalysts;2024-01-26
4. Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy;Science Advances;2024-01-26
5. Self-driving laboratories to autonomously navigate the protein fitness landscape;Nature Chemical Engineering;2024-01-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3