Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd.2017.170.pdf
Reference227 articles.
1. Wynn, T. A. & Ramalingam, T. R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat. Med. 18, 1028–1040 (2012).
2. Wynn, T. A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 117, 524–529 (2007).
3. Idiopathic Pulmonary Fibrosis Clinical Research Network et al. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N. Engl. J. Med. 366, 1968–1977 (2012). This study clearly demonstrated that patients with IPF treated with a combination of prednisone, azathioprine and NAC have an increased risk of death and hospitalization, supporting the notion that IPF is not an inflammatory-driven disease.
4. King, T. E. Jr. et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 370, 2083–2092 (2014). This phase III study confirms and extends the findings that pirfenidone reduces disease progression in IPF patients with mild-to-moderate physiological impairment with an acceptable side-effect profile.
5. Richeldi, L. et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N. Engl. J. Med. 370, 2071–2082 (2014). In both INPULSIS trials, it was shown that nintedanib, a potent kinase inhibitor blocking the effects of growth factors implicated in the pathogenesis of IPF, reduced the decline of FEV in patients with mild-to-moderate impairment of pulmonary function, which is consistent with a slowing of disease progression, and in general with tolerable adverse events.
Cited by 200 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. miR-765 as a promising biomarker for low-dose radiation-induced pulmonary fibrosis;Non-coding RNA Research;2024-03
2. A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models;Chinese Chemical Letters;2024-03
3. Circular RNAs and their roles in idiopathic pulmonary fibrosis;Respiratory Research;2024-02-06
4. Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1α;Cellular Signalling;2024-02
5. Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism;European Journal of Medical Research;2024-01-20
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3