Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation-Reference-Cited by-同舟云学术

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Published:2011-09 Issue:7365 Volume:477 Page:477-481
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Choi Jang Hyun,Banks Alexander S.,Kamenecka Theodore M.,Busby Scott A.,Chalmers Michael J.,Kumar Naresh,Kuruvilla Dana S.,Shin Youseung,He Yuanjun,Bruning John B.,Marciano David P.,Cameron Michael D.,Laznik Dina,Jurczak Michael J.,Schürer Stephan C.,Vidović Dušica,Shulman Gerald I.,Spiegelman Bruce M.,Griffin Patrick R.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature10383.pdf

Reference29 articles.

1. Lehmann, J. M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953–12956 (1995)

2. Choi, J. H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5. Nature 466, 451–456 (2010)

3. Tontonoz, P., Hu, E. & Spiegelman, B. M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147–1156 (1994)

4. Willson, T. M., Lambert, M. H. & Kliewer, S. A. Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu. Rev. Biochem. 70, 341–367 (2001)

5. Forman, B. M. et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803–812 (1995)

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