Genetics and pathogenesis of inflammatory bowel disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature10209.pdf
Reference100 articles.
1. Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genet. 42, 1118–1125 (2010). This study identifies 39 new loci containing genes in previously identified Crohn's-disease-relevant pathways, including IL10, IL27 and TYK2 , and reports the important genetic overlap with loci implicated in other immune-related diseases.
2. Anderson, C. A. et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genet. 43, 246–252 (2011). This study identifies 29 new loci containing genes that reinforce the contribution of epithelial barrier function, intracellular defence and cytokine-dependent signalling in ulcerative colitis, and it also reports genetic overlap with Crohn's disease.
3. Spehlmann, M. E. et al. Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm. Bowel Dis. 14, 968–976 (2008).
4. Yazdanyar, S., Kamstrup, P. R., Tybjaerg-Hansen, A. & Nordestgaard, B. G. Penetrance of NOD2/CARD15 genetic variants in the general population. Can. Med. Assoc. J. 182, 661–665 (2010).
5. Monick, M. M. et al. Identification of an autophagy defect in smokers' alveolar macrophages. J. Immunol. 185, 5425–5435 (2010).
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