IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells

Author:

Azar W J,Zivkovic S,Werther G A,Russo V C

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Reference79 articles.

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2. Jones JI, Clemmons DR . Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995; 16: 3–34.

3. Cohen P, Peehl DM, Stamey TA, Wilson KF, Clemmons DR, Rosenfeld RG . Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients. J Clin Endocrinol Metab 1993; 76: 1031–1035.

4. Busund LT, Richardsen E, Busund R, Ukkonen T, Bjornsen T, Busch C et al. Significant expression of igfbp2 in breast cancer compared with benign lesions. J Clin Pathol 2005; 58: 361–366.

5. So AI, Levitt RJ, Eigl B, Fazli L, Muramaki M, Leung S et al. Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer. Clin Cancer Res 2008; 14: 6944–6954.

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