Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

Author:

Ango F.,Prézeau L.,Muller T.,Tu J. C.,Xiao B.,Worley P. F.,Pin J. P.,Bockaert J.,Fagni L.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference27 articles.

1. Kenakin, T. Agonist-specific conformations. Trends Pharmacol. Sci. 18, 416–417 (1997).

2. Prezeau, L. et al. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Mol. Pharmacol. 49, 422–429 (1996).

3. Kato, A. et al. Novel members of Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J. Biol. Chem. 273, 23969–23975 (1998).

4. Xiao, B. et al. Homer regulates the association of group I metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron 21, 707–716 (1998).

5. Litschig, S. et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol. 55, 453–461 (1999).

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