Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology
Link
http://www.nature.com/articles/nsmb.3333.pdf
Reference55 articles.
1. Pirmohamed, M. Warfarin: almost 60 years old and still causing problems. Br. J. Clin. Pharmacol. 62, 509–511 (2006).
2. Rost, S. et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427, 537–541 (2004).
3. Li, T. et al. Identification of the gene for vitamin K epoxide reductase. Nature 427, 541–544 (2004).
4. Tie, J.-K. & Stafford, D.W. Structure and function of vitamin K epoxide reductase. Vitam. Horm. 78, 103–130 (2008).
5. Chu, P.-H., Huang, T.-Y., Williams, J. & Stafford, D.W. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proc. Natl. Acad. Sci. USA 103, 19308–19313 (2006).
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