The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer

Author:

Graham Douglas K.,DeRyckere Deborah,Davies Kurtis D.,Earp H. Shelton

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference199 articles.

1. Graham, D. K., Dawson, T. L., Mullaney, D. L., Snodgrass, H. R. & Earp, H. S. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5, 647–657 (1994). This paper describes the identification and sequencing of MERTK , as well as its expression in a range of cancer cell lines, including ectopic expression in lymphoblastic leukaemia.

2. O'Bryan, J. P. et al. AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell. Biol. 11, 5016–5031 (1991). This paper describes the identification and cloning of AXL from two independent samples from patients with CML, and transforming activity was shown in NIH3T3 cells.

3. Lai, C., Gore, M. & Lemke, G. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene 9, 2567–2578 (1994). This paper describes the identification, sequencing and transforming activity of TYRO3 in fibroblasts.

4. Linger, R. M., Keating, A. K., Earp, H. S. & Graham, D. K. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv. Cancer Res. 100, 35–83 (2008).

5. Lemke, G. & Rothlin, C. V. Immunobiology of the TAM receptors. Nature Rev. Immunol. 8, 327–336 (2008).

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