Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

Author:

Aliberti J.,Hieny S.,Reis e Sousa C.,Serhan C. N.,Sher A.

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference32 articles.

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2. Yap, G., Pesin, M. & Sher, A. Cutting edge: IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J. Immunol. 165, 628–631 (2000).

3. Gazzinelli, R. T. et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol. 157, 798–805 (1996).

4. Shevach, E. M., Chang, J. T. & Segal, B. M. The critical role of IL-12 and the IL-12R β 2 subunit in the generation of pathogenic autoreactive Th1 cells. Springer Semin. Immunopathol. 21, 249–262 (1999).

5. Braun, M. C. & Kelsall, B. L. Regulation of interleukin-12 production by G-protein-coupled receptors. Microbes Infect. 3, 99–107 (2001).

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