Abstract
AbstractThroughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of ‘cell competition’, can shift clone dynamics by evaluating the relative status of clonal populations, promoting ‘winners’ and eliminating ‘losers’. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.
Funder
Foundation for the National Institutes of Health
Pershing Square Foundation
Baillie Gifford Foundation
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Molecular Biology