Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3252.pdf
Reference182 articles.
1. Cohen, P. The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur. J. Biochem. 268, 5001–5010 (2001).
2. Verkhivker, G. M. Exploring sequence-structure relationships in the tyrosine kinome space: functional classification of the binding specificity mechanisms for cancer therapeutics. Bioinformatics 23, 1919–1926 (2007).
3. Giamas, G. et al. Kinases as targets in the treatment of solid tumors. Cell. Signal. 22, 984–1002 (2010).
4. Zsila, F., Fitos, I., Bencze, G., Keri, G. & Orfi, L. Determination of human serum α1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors. Curr. Med. Chem. 16, 1964–1977 (2009).
5. Cheng, H. & Force, T. Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ. Res. 106, 21–34 (2010).
Cited by 298 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling;Biomedicine & Pharmacotherapy;2024-02
2. Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312;Journal of Medicinal Chemistry;2023-12-26
3. Drug target, class level, and PathFX pathway information share utility for machine learning prediction of common drug-induced side effects;Frontiers in Drug Safety and Regulation;2023-11-23
4. Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor;Cell Chemical Biology;2023-10
5. Off-target pharmacological activity at various kinases: Potential functional and pathological side effects;Journal of Pharmacological and Toxicological Methods;2023-09
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3