Combination cancer immunotherapy and new immunomodulatory targets
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd4591.pdf
Reference270 articles.
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3. Gubin, M. M. et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, 577–581 (2014). Identifies tumour-specific mutant proteins (neoantigens) as the major T cell rejection targets following anti-PD1 and/or anti-CTLA4 tumour immunotherapy in mice. Vaccines incorporating these neoantigens can induce tumour rejection.
4. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000). Shows that PDL1 is a ligand for PD1 and inhibits T cell activation. It also shows that PDL1 expression is upregulated by IFN γ.
5. Blackburn, S. D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29–37 (2009). Shows that expression of multiple inhibitory receptors in addition to PD1 is associated with greater T cell exhaustion in a chronic viral infection model.
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