Combination cancer immunotherapy and new immunomodulatory targets
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd4591.pdf
Reference270 articles.
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4. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000). Shows that PDL1 is a ligand for PD1 and inhibits T cell activation. It also shows that PDL1 expression is upregulated by IFN γ.
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