Design and production of novel tetravalent bispecific antibodies

Author:

Coloma M. Josefina,Morrison Sherie L.

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference39 articles.

1. Flavell, D.J., Cooper, S., Morland, B. and Flavell, S.U. 1991. Characteristics and performance of a bispecific F (ab′gamma)2 antibody for delivering saporin to a CD7+ human acute T-cell leukaemia cell line. Br. J. Cancer 64: 274–280.

2. Runge, M.S., Bode, C., Savard, C.E., Matsueda, G.R. and Haber, E. 1990. Antibody-directed fibrinolysis: a bispecific (Fab′)2 that binds to fibrin and tissue plasminogen activator. Bioconjug. Chem. 1: 274–277.

3. Raso, V. and Griffin, T. 1981. Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells. Cancer Res. 41: 2073–2078.

4. Glennie, M.J., McBride, H.M., Worth, A.T. and Stevenson, G.T. 1987. Preparation and performance of bispecific F(ab′ gamma)2 antibody containing thioether-linked Fab′ gamma fragments. J. Immunol. 139: 2367–2375.

5. Glennie, M.J., Brennand, D.M., Bryden, F., McBride, H.M., Stirpe, F., Worth, A.T. and Stevenson, G.T., 1988. F(ab′ gamma)2 antibody for the delivery of saporin in the treatment of lymphoma. J. Immunol. 141: 3662–3670.

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