Stem cell repopulation efficiency but not pool size is governed by p27kip1

Author:

Cheng Tao,Rodrigues Neil,Dombkowski David,Stier Sebastian,Scadden David T.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference45 articles.

1. Mauch, P., Ferrara, J. & Hellman, S. Stem cell self-renewal considerations in bone marrow transplantation. Bone Marrow Transplant. 4, 601–607 (1989).

2. Mauch, P. et al. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 31, 1319–1339 (1995).

3. Gardner, R.V., Astle, C.M. & Harrison, D.E. Hematopoietic precursor cell exhaustion is a cause of proliferative defect in primitive hematopoietic stem cells (PHSC) after chemotherapy. Exp. Hematol. 25, 495–501 (1997).

4. Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21(cip1/waf1). Science 287, 1804–1808 (2000).

5. Polyak, K. et al. p27kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8, 9–22 (1994).

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