Abstract
AbstractThe intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair. A key part of the regenerative response is the transient reprogramming of epithelial cells into a fetal-like state, which drives uniform proliferation, tissue remodeling, and subsequent restoration of the homeostatic state. In this review, we discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development. Furthermore, we highlight how organoid-based applications have contributed to the characterization of the mechanistic principles and key players that guide these developmental and regenerative events.
Funder
ZonMw
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Oncode Institute
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Cited by
58 articles.
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