Molecular mechanisms of T cell co-stimulation and co-inhibition
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri3405.pdf
Reference134 articles.
1. June, C. H., Ledbetter, J. A., Gillespie, M. M., Lindsten, T. & Thompson, C. B. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7, 4472–4481 (1987). This paper identified CD28 as a co-stimulator that could amplify TCR signalling to induce proliferation and IL-2 production.
2. Bretscher, P. & Cohn, M. A theory of self-nonself discrimination. Science 169, 1042–1049 (1970). In this paper Bretscher and Cohn first proposed a model in which two signals would be required for cellular activation of B cells as a mechanism of self–non-self discrimination.
3. Mueller, D. L., Jenkins, M. K. & Schwartz, R. H. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445–480 (1989). This paper showed that TCR signalling in the absence of additional signals was insufficient to activate T cells and rendered T cells unresponsive to subsequent stimulation.
4. Liechtenstein, T., Dufait, I., Lanna, A., Breckpot, K. & Escors, D. Modulating co-stimulation during antigen presentation to enhance cancer immunotherapy. Immunol. Endocr. Metab. Agents Med. Chem. 12, 224–235 (2012).
5. Saito, T., Yokosuka, T. & Hashimoto-Tane, A. Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. FEBS Lett. 584, 4865–4871 (2010).
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