microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
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Published:2024-02-05
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ISSN:2058-5276
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Container-title:Nature Microbiology
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language:en
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Short-container-title:Nat Microbiol
Author:
Zuffa SimoneORCID, Schmid RobinORCID, Bauermeister Anelize, P. Gomes Paulo WenderORCID, Caraballo-Rodriguez Andres M., El Abiead Yasin, Aron Allegra T., Gentry Emily C.ORCID, Zemlin Jasmine, Meehan Michael J., Avalon Nicole E.ORCID, Cichewicz Robert H., Buzun Ekaterina, Terrazas Marvic Carrillo, Hsu Chia-YunORCID, Oles Renee, Ayala Adriana Vasquez, Zhao Jiaqi, Chu HiutungORCID, Kuijpers Mirte C. M.ORCID, Jackrel Sara L., Tugizimana Fidele, Nephali Lerato Pertunia, Dubery Ian A.ORCID, Madala Ntakadzeni Edwin, Moreira Eduarda Antunes, Costa-Lotufo Leticia Veras, Lopes Norberto PeporineORCID, Rezende-Teixeira Paula, Jimenez Paula C., Rimal Bipin, Patterson Andrew D.ORCID, Traxler Matthew F.ORCID, Pessotti Rita de CassiaORCID, Alvarado-Villalobos Daniel, Tamayo-Castillo GiselleORCID, Chaverri Priscila, Escudero-Leyva EfrainORCID, Quiros-Guerrero Luis-ManuelORCID, Bory Alexandre Jean, Joubert Juliette, Rutz Adriano, Wolfender Jean-LucORCID, Allard Pierre-MarieORCID, Sichert AndreasORCID, Pontrelli SammyORCID, Pullman Benjamin S., Bandeira Nuno, Gerwick William H., Gindro Katia, Massana-Codina JosepORCID, Wagner Berenike C.ORCID, Forchhammer KarlORCID, Petras DanielORCID, Aiosa Nicole, Garg Neha, Liebeke ManuelORCID, Bourceau Patric, Kang Kyo BinORCID, Gadhavi HennaORCID, de Carvalho Luiz Pedro Sorio, Silva dos Santos MarianaORCID, Pérez-Lorente Alicia Isabel, Molina-Santiago CarlosORCID, Romero DiegoORCID, Franke RaimoORCID, Brönstrup MarkORCID, Vera Ponce de León Arturo, Pope Phillip ByronORCID, La Rosa Sabina LeantiORCID, La Barbera GiorgiaORCID, Roager Henrik M.ORCID, Laursen Martin FrederikORCID, Hammerle Fabian, Siewert Bianka, Peintner Ursula, Licona-Cassani Cuauhtemoc, Rodriguez-Orduña LorenaORCID, Rampler Evelyn, Hildebrand FelinaORCID, Koellensperger Gunda, Schoeny HaraldORCID, Hohenwallner KatharinaORCID, Panzenboeck LisaORCID, Gregor Rachel, O’Neill Ellis CharlesORCID, Roxborough Eve Tallulah, Odoi Jane, Bale Nicole J., Ding SuORCID, Sinninghe Damsté Jaap S., Guan Xue LiORCID, Cui Jerry J.ORCID, Ju Kou-SanORCID, Silva Denise Brentan, Silva Fernanda Motta Ribeiro, da Silva Gilvan Ferreira, Koolen Hector H. F., Grundmann Carlismari, Clement Jason A., Mohimani HoseinORCID, Broders Kirk, McPhail Kerry L.ORCID, Ober-Singleton Sidnee E., Rath Christopher M., McDonald Daniel, Knight Rob, Wang Mingxun, Dorrestein Pieter C.ORCID
Abstract
AbstractmicrobeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms’ role in ecology and human health.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases U.S. Department of Health & Human Services | NIH | National Institute on Aging
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology
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