A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Author:

Yang Suk-Kyun,Hong Myunghee,Baek Jiwon,Choi Hyunchul,Zhao Wanting,Jung Yusun,Haritunians Talin,Ye Byong Duk,Kim Kyung-Jo,Park Sang Hyoung,Park Soo-Kyung,Yang Dong-Hoon,Dubinsky Marla,Lee Inchul,McGovern Dermot P B,Liu Jianjun,Song Kyuyoung

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference19 articles.

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2. Prefontaine, E., Sutherland, L.R., Macdonald, J.K. & Cepoiu, M. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease. Cochrane Database Syst. Rev. 1, CD000067 (2009).

3. Present, D.H., Meltzer, S.J., Krumholz, M.P., Wolke, A. & Korelitz, B.I. 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann. Intern. Med. 111, 641–649 (1989).

4. Connell, W.R., Kamm, M.A., Ritchie, J.K. & Lennard-Jones, J.E. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut 34, 1081–1085 (1993).

5. Fraser, A.G., Orchard, T.R. & Jewell, D.P. The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review. Gut 50, 485–489 (2002).

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