Abstract
Abstract
Background
Although overall alcohol consumption is known to increase the risk of a number of cancers internationally, evidence for Australia and evidence regarding the pattern of drinking and cancer risk is limited.
Methods
Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for cancer risk in relation to overall alcohol consumption (drinks/week) and pattern of drinking were calculated using Cox proportional hazard regressions for 226,162 participants aged ≥45 years (2006–2009) in the 45 and Up Study, an Australian prospective cohort study. Incident primary cancer cases were ascertained by linkage to the New South Wales Cancer Registry to 2013 by the Centre for Health Record Linkage.
Results
Over a median of 5.4 years, 17,332 cancers were diagnosed. Increasing levels of alcohol intake were associated with increased risk of cancers of the upper aerodigestive tract (1.19; 1.10–1.29), mouth and pharynx (1.18; 1.08–1.29), oesophagus (1.22; 1.04–1.43), colorectum (1.09; 1.04–1.15), colon (1.13; 1.06–1.20), liver (1.22; 1.04–1.44) and breast (1.11; 1.02–1.21). Breast cancer risk was marginally associated with drinking pattern, with higher risk when intake was concentrated on 1–3 days/week compared to the same amount spread over 4–7 days (Pinteraction = 0.049).
Conclusions
Alcohol consumption confers a significant risk of cancer, and drinking pattern may be independently related to breast cancer risk.
Funder
Cancer Council NSW
Department of Health | National Health and Medical Research Council
Publisher
Springer Science and Business Media LLC
Reference69 articles.
1. Australian Bureau of Statistics. National Health Survey: First Results 2017–18 (ABS, Canberra, 2018).
2. World Health Organisation. Global Status Report on Alcohol and Health 2018 (WHO, Geneva, 2018).
3. Pandeya, N., Wilson, L. F., Webb, P. M., Neale, R. E., Bain, C. J. & Whiteman, D. C. Cancers in Australia in 2010 attributable to the consumption of alcohol. Aust. N. Z. J. Public Health 39, 408–413 (2015).
4. Praud, D., Rota, M., Rehm, J., Shield, K., Zatonski, W., Hashibe, M. et al. Cancer incidence and mortality attributable to alcohol consumption. Int. J. Cancer 138, 1380–1387 (2016).
5. Australian Institute of Health and Welfare. Australian Burden of Disease Study: Impact and Causes of Illness and Death in Australia 2015 (AIHW, Canberra, 2019).
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献