Long non-coding RNAs are involved in alternative splicing and promote cancer progression

Author:

Ouyang Jiawei,Zhong Yu,Zhang Yijie,Yang Liting,Wu Pan,Hou Xiangchan,Xiong Fang,Li Xiayu,Zhang Shanshan,Gong Zhaojian,He Yi,Tang Yanyan,Zhang Wenling,Xiang Bo,Zhou Ming,Ma Jian,Li Yong,Li Guiyuan,Zeng ZhaoyangORCID,Guo CanORCID,Xiong WeiORCID

Abstract

AbstractAlternative splicing (AS) is a key process in which precursor RNAs produce different mature RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared with coding RNA, studies on the functions of long non-coding RNAs (lncRNAs) are far from enough. In fact, lncRNA is an important participant and regulator in the process of AS. On the one hand, lncRNAs regulate cancer progression as AS products of precursor messenger RNA (mRNA), but on the other hand, precursor lncRNA generates cancer-related abnormal splicing variants through AS. In addition, lncRNAs directly or indirectly regulate the AS events of downstream target genes, thus affecting the occurrence and development of cancer. Here, we reviewed how lncRNAs regulate AS and influence oncogenesis in different ways.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

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