Abstract
AbstractRatings on the Positive and Negative Syndrome Scale (PANSS) are ideally based on both a patient interview and an informant questionnaire. In research and clinical settings, however, the informant questionnaire is often omitted. This study investigated the consequences of omitting informant information by comparing PANSS ratings of patients with schizophrenia (n = 49 patients, 77 ratings) conducted with and without informant information, respectively. Additionally, changes in symptom severity over time based on ratings with and without informant information were also compared for the full PANSS and the six-item version of the PANSS (PANSS-6). PANSS ratings including informant information were higher than those without, both at the total score and individual item level. Additionally, the full PANSS appeared less “responsive” to baseline-to-endpoint changes for ratings without informant information compared to ratings including informant information, while no differences were found for the PANSS-6.
Publisher
Springer Science and Business Media LLC
Reference24 articles.
1. Correll, C. U., Kishimoto, T., Nielsen, J. & Kane, J. M. Quantifying clinical relevance in the treatment of schizophrenia. Clin. Ther. 33, B16–B39 (2011).
2. Kay, S. R., Fiszbein, A. & Opler, L. A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13, 261–276 (1987).
3. Kay, S. R., Opler, L. A. & Lindenmayer, J. Structured Clinical Interview for the PANSS (SCI-PANSS) (Multi-Health Systems, 1992).
4. Kay, S. R., Opler, L. A. & Fiszbein, A. Positive and Negative Syndrome Scale (PANSS): Manual (Multi-Health Systems, Inc., 2006).
5. Meltzer, H. Y. et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am. J. Psychiatry 168, 957–967 (2011).