Abstract
AbstractDespite the consistent finding of an attenuated niacin-induced flush response in schizophrenia, its long-term stability and relationship to the membrane polyunsaturated fatty acid (PUFA) levels remain unknown. We conducted niacin skin tests and measured the membrane PUFAs using gas chromatography among 46 schizophrenia inpatients and 37 healthy controls at the baseline and the 2-month follow-up. Attenuated flush responses were persistently observed in schizophrenia patients in both acute and partial remission states, whereas an increased flush response was found in the controls. A persistent decrease in both dihomo-gamma-linolenic acid and docosahexaenoic acid and an increased turnover of arachidonic acid (ARA) via endogenous biosynthesis were found in schizophrenia patients. A composite niacin flush score by combining those with a control-to-case ratio of >1.4 (i.e., scores at 5 min of 0.1 M, 0.01 M, and 0.001 M + 10 min of 0.01 M and 0.001 M + 15 min of 0.001 M) at the baseline was correlated positively with ARA levels among controls but not among schizophrenia patients, whereas the flush score at the 2-month follow-up was correlated positively with ARA levels among patients. The 2-month persistence of attenuated niacin-induced flush response in schizophrenia patients implies that the niacin skin test might tap a long-term vulnerability to schizophrenia beyond acute exacerbation.
Funder
Ministry of Science and Technology, Taiwan
Publisher
Springer Science and Business Media LLC
Reference88 articles.
1. Smesny, S. et al. Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia. Prostaglandins Leukot. Essent. Fatty Acids 77, 79–85 (2007).
2. Yao, J. K. et al. Prevalence and specificity of the abnormal niacin response: a potential endophenotype marker in schizophrenia. Schizophr. Bull. 42, 369–376 (2016).
3. Messamore, E. The niacin response biomarker as a schizophrenia endophenotype: a status update. Prostaglandins Leukot. Essent. Fatty Acids 136, 95–97 (2018).
4. Messamore, E., Hoffman, W. F. & Janowsky, A. The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study. Schizophr. Res. 62, 251–258 (2003).
5. Buretic-Tomljanovic, A. et al. Phospholipid membrane abnormalities and reduced niacin skin flush response in schizophrenia. Psychiatr. Danub. 20, 372–383 (2008).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献