Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

Author:

Shih Diana M.,Gu Lingjie,Xia Yu-Rong,Navab Mohamad,Li Wan-Fen,Hama Susan,Castellani Lawrence W.,Furlong Clement E.,Costa Lucio G.,Fogelman Alan M.,Lusis Aldons J.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference17 articles.

1. Murphy, S. D. in Toxicology: The Basic Science of Poisons(eds Doull, J., Klassen, C. & Amdur, M.) 357–408 (Macmillan, New York, (1980)).

2. Tafuri, J. & Roberts, J. Organophosphate poisoning. Ann. Emerg. Med. 16, 193–202 (1987).

3. Smolen, A., Eckerson, H. W., Gan, K. N., Hailat, N. & La Du, B. N. Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase. Drug Metab. Dispos. 19, 107–112 (1991).

4. Mackness, M. I., Arrol, S. & Durrington, P. N. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 286, 152–154 (1991).

5. Watson, A. D. et al. Protective effect of HDL associated paraoxonase-inhibition of the biological activity of minimally oxidized low density lipoprotein. J. Clin. Invest. 96, 2882–2891 (1995).

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