Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
https://www.nature.com/articles/s41586-023-06609-0.pdf
Reference36 articles.
1. Owen, D. R. et al. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19. Science 374, 1586–1593 (2021).
2. Hammond, J. et al. Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19. New Engl. J. Med. 386, 1397–1408 (2022).
3. Iketani, S. et al. Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Nature https://doi.org/10.1038/s41586-022-05514-2 (2022).
4. Wang, Q. et al. Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5. Nature https://doi.org/10.1038/s41586-022-05053-w (2022).
5. Wong, C. K. H. et al. Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort study. Lancet Infect. Dis. https://doi.org/10.1016/S1473-3099(22)00507-2 (2022).
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