Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
https://www.nature.com/articles/s41586-022-05290-z.pdf
Reference39 articles.
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2. Stepan, A. F. et al. Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor. J. Med. Chem. 55, 3414–3424 (2012).
3. Auberson, Y. P. et al. Improving nonspecific binding and solubility: bicycloalkyl groups and cubanes as para-phenyl bioisosteres. Chem. Med. Chem. 12, 590–598 (2017).
4. Ma, X. & Pham, Nhat L. Selected topics in the syntheses of bicyclo[1.1.1]pentane (BCP) analogues. Asian J. Org. Chem. 9, 8–22 (2020).
5. Mykhailiuk, P. K. Saturated bioisosteres of benzene: where to go next? Org. Biomol. Chem. 17, 2839–2849 (2019).
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