T cells specific for α-myosin drive immunotherapy-related myocarditis-Reference-Cited by-同舟云学术

T cells specific for α-myosin drive immunotherapy-related myocarditis

Published:2022-11-16 Issue:7937 Volume:611 Page:818-826
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Axelrod Margaret L.^ORCID,Meijers Wouter C.,Screever Elles M.,Qin Juan^ORCID,Carroll Mary Grace,Sun Xiaopeng,Tannous Elie,Zhang Yueli,Sugiura Ayaka^ORCID,Taylor Brandie C.,Hanna Ann,Zhang Shaoyi^ORCID,Amancherla Kaushik,Tai Warren^ORCID,Wright Jordan J.^ORCID,Wei Spencer C.,Opalenik Susan R.,Toren Abigail L.,Rathmell Jeffrey C.^ORCID,Ferrell P. Brent^ORCID,Phillips Elizabeth J.^ORCID,Mallal Simon,Johnson Douglas B.^ORCID,Allison James P.,Moslehi Javid J.,Balko Justin M.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-022-05432-3.pdf

Reference63 articles.

1. Wang, D. Y. et al. Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA Oncol. 4, 1721–1728 (2018).

2. Wei, S. C. et al. A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention. Cancer Discov. 11, 614–639 (2020).

3. Lv, H. et al. Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. J. Clin. Invest. 121, 1561–1573 (2011).

4. Gabrielsen, I. S. M. et al. Transcriptomes of antigen presenting cells in human thymus. PLoS ONE 14, e0218858 (2019).

5. Johnson, D. B. et al. Fulminant myocarditis with combination immune checkpoint blockade. N. Engl. J. Med. 375, 1749–1755 (2016).

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