The final steps of integrin activation: the end game
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2871.pdf
Reference155 articles.
1. Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673–687 (2002).
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3. Petrich, B. G. et al. The antithrombotic potential of selective blockade of talin-dependent integrin αIIbβ3 (platelet GPIIb-IIIa) activation. J. Clin. Invest. 117, 2250–2259 (2007). Shows that the mutational inhibition of talin 1 binding to the β3 integrin tail prevents activation of αIIbβ3 integrin, resulting in protection from thrombosis without spontaneous pathological bleeding.
4. Carman, C. V. & Springer, T. A. Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr. Opin. Cell Biol. 15, 547–556 (2003).
5. Bazzoni, G. & Hemler, M. E. Are changes in integrin affinity and conformation overemphasized? Trends Biochem. Sci. 23, 30–34 (1998).
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