1. Steele, F. R., Chader, G. J., Johnson, L. V. & Tombran-Tink, J. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc. Natl Acad. Sci. USA 90, 1526–1530 (1993). The first article to report the complete sequence of the human PEDF mRNA and protein, and its identification as a member of the serpin gene family with neurotrophic activity on retinoblastoma tumour cells.
2. Tombran-Tink, J., Chader, G. G. & Johnson, L. V. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp. Res. 53, 411–414 (1991).
3. Doggett, D. L., Rotenberg, M. O., Pignolo, R. J., Phillips, P. D. & Cristofalo, V. J. Differential gene expression between young and senescent, quiescent WI-38 cells. Mech. Ageing Dev. 65, 239–255 (1992).
4. Pignolo, R. J., Cristofalo, V. J. & Rotenberg, M. O. Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state. J. Biol. Chem. 268, 8949–8957 (1993). This report describes how SERPINF1 is a gene that is induced to ≥100-fold levels in young lung fibroblast cells relative to senescent cells, which fail to express it, and is a first association of PEDF with ageing.
5. Francis, M. K. et al. Loss of EPC-1/PEDF expression during skin aging in vivo. J. Invest. Dermatol. 122, 1096–1105 (2004).