Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2450.pdf
Reference137 articles.
1. Takahama, Y. Journey through the thymus: stromal guides for T-cell development and selection. Nature Rev. Immunol. 6, 127–135 (2006).
2. Anderson, G., Lane, P. J. & Jenkinson, E. J. Generating intrathymic microenvironments to establish T-cell tolerance. Nature Rev. Immunol. 7, 954–963 (2007).
3. Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33–45 (2005). Using computational analyses of microarray data on medullary RNA transcripts from AIRE-deficient and wild-type mice, references 3 and 96 show that there is a significant degree of clustering of AIRE target genes.
4. Kyewski, B. & Klein, L. A central role for central tolerance. Annu. Rev. Immunol. 24, 571–606 (2006). This is an excellent review of promiscuous gene expression and the role of AIRE in central tolerance.
5. Gallegos, A. M. & Bevan, M. J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004).
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