Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38

Author:

Mathijssen R H J,Verweij J,Loos W J,de Bruijn P,Nooter K,Sparreboom A

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference29 articles.

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2. Chu XY, Kato Y, Ueda K, Suzuki H, Niinuma K, Tyson CA, Weizer V, Dabbs JE, Froehlich R, Green CE, Sugiyama Y (1998) Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. Cancer Res 58: 5137–5143

3. Chu XY, Kato Y, Sugiyama Y (1999) Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats. Drug Metab Dispos 27: 440–441

4. De Bruijn P, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A (1997) Determination of irinotecan (CPT-11) and its active metabolite SN-38 in human plasma by reversed-phase high-performance liquid chromatography with fluorescence detection. J Chromatogr 698: 277–285

5. De Bruijn P, de Jonge MJA, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A (1999) Femtomole quantitation of 7-ethyl-10-hydroxycamptothecine (SN-38) in plasma samples by reversed-phase high-performance liquid chromatography. Anal Biochem 269: 174–178

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