Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation-Reference-Cited by-同舟云学术

Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation

Published:2020-03-31 Issue:20 Volume:39 Page:4103-4117
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Ricciardiello Francesca,Gang Yang^ORCID,Palorini Roberta,Li Quanxiao,Giampà Marco,Zhao Fangyu,You Lei,La Ferla Barbara,De Vitto Humberto,Guan Wenfang,Gu Jin^ORCID,Zhang Taiping,Zhao Yupei,Chiaradonna Ferdinando^ORCID

Funder

Ministero degli Affari Esteri e della Cooperazione Internazionale

Associazione Italiana per la Ricerca sul Cancro

Ministero dell'Istruzione, dell'Università e della Ricerca

National Brazilian Institution of Science

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/s41388-020-1260-1.pdf

Reference45 articles.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

2. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74:2913–21.

3. Binenbaum Y, Na'ara S, Gil Z. Gemcitabine resistance in pancreatic ductal adenocarcinoma. Drug Resist Updat. 2015;23:55–68.

4. Amrutkar M, Gladhaug IP. Pancreatic cancer chemoresistance to gemcitabine. Cancers. 2017;9:157.

5. de Sousa Cavalcante L, Monteiro G. Gemcitabine: metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharm. 2014;741:8–16.

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