Rapamycin passes the torch: a new generation of mTOR inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3531.pdf
Reference163 articles.
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2. Martel, R. R., Klicius, J. & Galet, S. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55, 48–51 (1977).
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4. Heitman, J., Movva, N. R. & Hall, M. N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905–909 (1991). The discovery of TOR by genetic selection in yeast. This study not only discovered the cellular target of rapamycin but also elucidated its mode of action via binding to the FPR1 gene product (the yeast homologue of mammalian FKBP12).
5. Zoncu, R., Efeyan, A. & Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev. Mol. Cell Biol. 12, 21–35 (2011).
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