Author:
Kong Kangjie,Wang Peiyuan,Xie Zihong,Wang Lu,Jiang Jiaxuan,Liu Yaoming,Du Shaolin,Jiang Jingwen,Song Yunhe,Lin Fengbin,Wang Wei,Fang Xiuli,Shi Zhuoxing,Zhang Xiulan,Chen Shida
Abstract
AbstractMice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis. This invaluable dataset offers a comprehensive transcriptomic resource of mRNA and lncRNA expression profiles during the natural progression of retinal development and aging. The discoveries stemming from this investigation will significantly contribute to the elucidation of the underlying molecular mechanisms associated with various retinal diseases, such as congenital retinal dysplasia and retinal degenerative diseases.
Funder
National Key Research and Development Program of ChinaNatural Science Foundation of Guangdong province of China Science and Technology Program of Guangzhou, China
National Natural Science Foundation of China High-level Hospital Construction Project, Zhongshan Ophthalmic Center, Sun Yat-sen University
Publisher
Springer Science and Business Media LLC
Subject
Library and Information Sciences,Statistics, Probability and Uncertainty,Computer Science Applications,Education,Information Systems,Statistics and Probability