Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9-Reference-Cited by-同舟云学术

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Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

Published:2016-01-11 Issue:2 Volume:34 Page:192-198
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Korkmaz Gozde,Lopes Rui,Ugalde Alejandro P,Nevedomskaya Ekaterina,Han Ruiqi,Myacheva Ksenia,Zwart Wilbert,Elkon Ran,Agami Reuven

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.3450.pdf

Reference38 articles.

1. Sexton, T. & Cavalli, G. The role of chromosome domains in shaping the functional genome. Cell 160, 1049–1059 (2015).

2. Mansour, M.R. et al. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 346, 1373–1377 (2014).

3. Vahedi, G. et al. Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature 520, 558–562 (2015).

4. Shi, J. & Vakoc, C.R. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol. Cell 54, 728–736 (2014).

5. Cho, S.W., Kim, S., Kim, J.M. & Kim, J.S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31, 230–232 (2013).

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1. Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency;Nucleic Acids Research;2024-09-04

2. The enhancer RNA, AANCR, regulates APOE expression in astrocytes and microglia;Nucleic Acids Research;2024-08-20

3. Harnessing the evolving CRISPR/Cas9 for precision oncology;Journal of Translational Medicine;2024-08-08

4. A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence;Cell;2024-08

5. Epigenome editing technologies for discovery and medicine;Nature Biotechnology;2024-07-29

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