Author:
Li Erna,Wei Xiao,Ma Yanyan,Yin Zhe,Li Huan,Lin Weishi,Wang Xuesong,Li Chao,Shen Zhiqiang,Zhao Ruixiang,Yang Huiying,Jiang Aimin,Yang Wenhui,Yuan Jing,Zhao Xiangna
Abstract
Abstract
Enterobacter aerogenes (Enterobacteriaceae) is an important opportunistic pathogen that causes hospital-acquired pneumonia, bacteremia, and urinary tract infections. Recently, multidrug-resistant E. aerogenes have been a public health problem. To develop an effective antimicrobial agent, bacteriophage phiEap-2 was isolated from sewage and its genome was sequenced because of its ability to lyse the multidrug-resistant clinical E. aerogenes strain 3-SP. Morphological observations suggested that the phage belongs to the Siphoviridae family. Comparative genome analysis revealed that phage phiEap-2 is related to the Salmonella phage FSL SP-031 (KC139518). All of the structural gene products (except capsid protein) encoded by phiEap-2 had orthologous gene products in FSL SP-031 and Serratia phage Eta (KC460990). Here, we report the complete genome sequence of phiEap-2 and major findings from the genomic analysis. Knowledge of this phage might be helpful for developing therapeutic strategies against E. aerogenes.
Publisher
Springer Science and Business Media LLC
Cited by
30 articles.
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