Homeostatic proliferation is a barrier to transplantation tolerance

Author:

Wu Zihao,Bensinger Steven J,Zhang Jidong,Chen Chuangqi,Yuan Xueli,Huang Xiaolun,Markmann James F,Kassaee Alireza,Rosengard Bruce R,Hancock Wayne W,Sayegh Mohamed H,Turka Laurence A

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference30 articles.

1. Valujskikh, A., Pantenburg, B. & Heeger, P.S. Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am. J. Transpl. 2, 501–509 (2002).

2. Onodera, K. et al. CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses. J. Immunol. 159, 1711–1717 (1997).

3. Li, Y. et al. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat. Med. 5, 1298–1302 (1999).

4. Wells, A.D. et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med. 5, 1303–1307 (1999).

5. Kirk, A.D. et al. Results from a human tolerance trial using CAMPATH-1H with and without infliximab. Am. J. Transpl. 2 (suppl. 3), 379 (2002).

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