Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum-Reference-Cited by-同舟云学术

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Published:2015-12 Issue:1 Volume:6 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Wang Jigang,Zhang Chong-Jing,Chia Wan Ni,Loh Cheryl C. Y.,Li Zhengjun,Lee Yew Mun^ORCID,He Yingke,Yuan Li-Xia,Lim Teck Kwang,Liu Min,Liew Chin Xia^ORCID,Lee Yan Quan,Zhang Jianbin,Lu Nianci,Lim Chwee Teck,Hua Zi-Chun,Liu Bin,Shen Han-Ming,Tan Kevin S. W.,Lin Qingsong

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms10111.pdf

Reference68 articles.

1. Manske, M. et al. Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375–379 (2012).

2. Nosten, F. & White, N. J. Artemisinin-based combination treatment of falciparum malaria. Am. J. Trop. Med. Hyg. 77, 181–192 (2007).

3. Meshnick, S. R. Artemisinin: mechanisms of action, resistance and toxicity. Int. J. Parasitol. 32, 1655–1660 (2002).

4. Meunier, B. & Robert, A. Heme as trigger and target for trioxane-containing antimalarial drugs. Acc. Chem. Res. 43, 1444–1451 (2010).

5. Meshnick, S. R. et al. Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrob. Agents Chemother. 37, 1108–1114 (1993).

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