Landscape of somatic alterations in large-scale solid tumors from an Asian population
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Published:2022-07-23
Issue:1
Volume:13
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Wu Liqun, Yao HeruiORCID, Chen Hui, Wang Aodi, Guo Kun, Gou Wenli, Yu Yanfei, Li Xiang, Yao Ming, Yuan Shaohua, Pang Fei, Hu Jinwei, Chen Lijuan, Liu Wenjin, Yao Jicheng, Zhang Shuirong, Dong Xiaowei, Wang Weifeng, Hu Jing, Ling QiORCID, Ding Songming, Wei Yan, Li Qiang, Cao Weichun, Wang Shuang, Di Yang, Feng Feiling, Zhao Gang, Zhang Jian, Huang Ling, Xu Jia, Yan Wangjun, Tong Zhongsheng, Jiang Da, Ji TaoORCID, Li Qiao, Xu Ling, He HuiyingORCID, Shang Liang, Liu Jin, Wang Kefeng, Wu Duoguang, Shen JingnanORCID, Liu Ye, Zhang Ting, Liang Chaojie, Wang Yusheng, Shang Yanhong, Guo Jianji, Liang Guanbiao, Xu Shifeng, Liu Junfeng, Wang KaiORCID, Wang Minghui
Abstract
AbstractExtending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tumor tissues and matched blood specimens from over 10,000 patients in China by using a 450-gene comprehensive assay, developed and implemented under international clinical regulations. We perform a comprehensive comparison of somatically altered genes, the distribution of tumor mutational burden (TMB), gene fusion patterns, and the spectrum of various somatic alterations between Chinese and American patient populations. Here, we show 64% of cancers from Chinese patients in this study have clinically actionable genomic alterations, which may affect clinical decisions related to targeted therapy or immunotherapy. These findings describe the similarities and differences between tumors from Chinese and American patients, providing valuable information for personalized medicine.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
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