Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer

Author:

Tundidor Isabel,Seijo-Vila Marta,Blasco-Benito Sandra,Rubert-Hernández María,Adámez SandraORCID,Andradas Clara,Manzano SaraORCID,Álvarez-López Isabel,Sarasqueta Cristina,Villa-Morales MaríaORCID,González-Lois CarmenORCID,Ramírez-Medina Esther,Almoguera BelénORCID,Sánchez-López Antonio J.,Bindila LauraORCID,Hamann Sigrid,Arnold NorbertORCID,Röcken ChristophORCID,Heras-Murillo Ignacio,Sancho DavidORCID,Moreno-Bueno GemaORCID,Caffarel María M.ORCID,Guzmán ManuelORCID,Sánchez CristinaORCID,Pérez-Gómez EduardoORCID

Abstract

AbstractClinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is susceptible to metastatic relapse as late as 15 years after treatment discontinuation. Seeking therapeutic approaches as well as screening tools to properly identify those patients with a higher risk of recurrence is therefore essential. Here, we report that the lipid-degrading enzyme fatty acid amide hydrolase (FAAH) is a predictor of long-term survival in patients with luminal BC, and that it blocks tumor progression and lung metastasis in cell and mouse models of BC. Together, our findings highlight the potential of FAAH as a biomarker with prognostic value in luminal BC and as a therapeutic target in metastatic disease.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

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