Personalized functional brain network topography is associated with individual differences in youth cognition
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Published:2023-12-18
Issue:1
Volume:14
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Keller Arielle S.ORCID, Pines Adam R., Shanmugan Sheila, Sydnor Valerie J.ORCID, Cui ZaixuORCID, Bertolero Maxwell A.ORCID, Barzilay Ran, Alexander-Bloch Aaron F.ORCID, Byington Nora, Chen AndrewORCID, Conan Gregory M., Davatzikos ChristosORCID, Feczko Eric, Hendrickson Timothy J.ORCID, Houghton AudreyORCID, Larsen Bart, Li Hongming, Miranda-Dominguez OscarORCID, Roalf David R.ORCID, Perrone Anders, Shetty Alisha, Shinohara Russell T., Fan Yong, Fair Damien A.ORCID, Satterthwaite Theodore D.ORCID
Abstract
AbstractIndividual differences in cognition during childhood are associated with important social, physical, and mental health outcomes in adolescence and adulthood. Given that cortical surface arealization during development reflects the brain’s functional prioritization, quantifying variation in the topography of functional brain networks across the developing cortex may provide insight regarding individual differences in cognition. We test this idea by defining personalized functional networks (PFNs) that account for interindividual heterogeneity in functional brain network topography in 9–10 year olds from the Adolescent Brain Cognitive Development℠ Study. Across matched discovery (n = 3525) and replication (n = 3447) samples, the total cortical representation of fronto-parietal PFNs positively correlates with general cognition. Cross-validated ridge regressions trained on PFN topography predict cognition in unseen data across domains, with prediction accuracy increasing along the cortex’s sensorimotor-association organizational axis. These results establish that functional network topography heterogeneity is associated with individual differences in cognition before the critical transition into adolescence.
Funder
U.S. Department of Health & Human Services | National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
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