Discovering human diabetes-risk gene function with genetics and physiological assays
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-06249-3.pdf
Reference52 articles.
1. Prasad, R. B. & Groop, L. Genetics of type 2 diabetes-pitfalls and possibilities. Genes 6, 87–123 (2015).
2. Scott, R. A. et al. An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes 66, 2888–2902 (2017).
3. Alfa, R. W. & Kim, S. K. Using Drosophila to discover mechanisms underlying type 2 diabetes. Dis. Models Mech. 9, 365–376 (2016).
4. Ikeya, T., Galic, M., Belawat, P., Nairz, K. & Hafen, E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12, 1293–1300 (2002).
5. Rulifson, E. J., Kim, S. K. & Nusse, R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118–1120 (2002).
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