Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB

Author:

Yang Rui-Meng,Song Shi-Yang,Wu Feng-Yao,Yang Rui-FengORCID,Shen Yan-TingORCID,Tu Ping-Hui,Wang Zheng,Zhang Jun-Xiu,Cheng Feng,Gao Guan-Qi,Liang Jun,Guo Miao-Miao,Yang Liu,Zhou Yi,Zhao Shuang-XiaORCID,Zhan Ming,Song Huai-DongORCID

Abstract

AbstractThe pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes located at the center of thyroid tissues in postnatal mice, which maintained a partially mesenchymal phenotype. These cells actively protruded out of the thyroid primordium and generated new follicles in zebrafish embryos through continuous tracing. Suppressing NF-κB signaling affected thyrocyte migration and follicle formation, leading to a TD-like phenotype in both mice and zebrafish. Interestingly, during thyroid folliculogenesis, myeloid cells played a crucial role in promoting thyrocyte migration by maintaining close contact and secreting TNF-α. We found that cebpa mutant zebrafish, in which all myeloid cells were depleted, exhibited thyrocyte migration defects. Taken together, our results suggest that myeloid-derived TNF-α-induced NF-κB activation plays a critical role in promoting the migration of vertebrate thyrocytes for follicle generation.

Funder

National Natural Science Foundation of China

National Key R&D Program of China

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

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