Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
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Published:2023-05-16
Issue:1
Volume:14
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Tamura TomokazuORCID, Ito JumpeiORCID, Uriu Keiya, Zahradnik JiriORCID, Kida IzumiORCID, Anraku YukiORCID, Nasser HeshamORCID, Shofa Maya, Oda Yoshitaka, Lytras SpyrosORCID, Nao Naganori, Itakura YukariORCID, Deguchi Sayaka, Suzuki Rigel, Wang LeiORCID, Begum MST Monira, Kita ShunsukeORCID, Yajima Hisano, Sasaki Jiei, Sasaki-Tabata Kaori, Shimizu Ryo, Tsuda MasumiORCID, Kosugi Yusuke, Fujita ShigeruORCID, Pan Lin, Sauter DanielORCID, Yoshimatsu KumikoORCID, Suzuki SaoriORCID, Asakura Hiroyuki, Nagashima Mami, Sadamasu Kenji, Yoshimura Kazuhisa, Yamamoto Yuki, Nagamoto Tetsuharu, Schreiber GideonORCID, Maenaka KatsumiORCID, Ito Hayato, Misawa Naoko, Kimura Izumi, Suganami Mai, Chiba Mika, Yoshimura Ryo, Yasuda Kyoko, Iida Keiko, Ohsumi Naomi, Strange Adam P., Takahashi Otowa, Ichihara Kimiko, Shibatani Yuki, Nishiuchi Tomoko, Kato Marie, Ferdous Zannatul, Mouri Hiromi, Shishido Kenji, Sawa Hirofumi, Hashimoto Rina, Watanabe Yukio, Sakamoto Ayaka, Yasuhara Naoko, Suzuki Tateki, Kimura Kanako, Nakajima Yukari, Nakagawa So, Wu Jiaqi, Shirakawa Kotaro, Takaori-Kondo Akifumi, Nagata Kayoko, Kazuma Yasuhiro, Nomura Ryosuke, Horisawa Yoshihito, Tashiro Yusuke, Kawai Yugo, Irie Takashi, Kawabata Ryoko, Motozono Chihiro, Toyoda Mako, Ueno Takamasa, Hashiguchi TakaoORCID, Ikeda TerumasaORCID, Fukuhara TakasukeORCID, Saito AkatsukiORCID, Tanaka ShinyaORCID, Matsuno KeitaORCID, Takayama Kazuo, Sato KeiORCID,
Abstract
AbstractIn late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.
Funder
Japan Agency for Medical Research and Development
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference96 articles.
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