Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
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Published:2022-05-10
Issue:1
Volume:13
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Patrono Livia V., Vrancken BramORCID, Budt Matthias, Düx Ariane, Lequime SebastianORCID, Boral Sengül, Gilbert M. Thomas P.ORCID, Gogarten Jan F., Hoffmann Luisa, Horst David, Merkel Kevin, Morens David, Prepoint BaptisteORCID, Schlotterbeck Jasmin, Schuenemann Verena J., Suchard Marc A.ORCID, Taubenberger Jeffery K.ORCID, Tenkhoff Luisa, Urban Christian, Widulin Navena, Winter Eduard, Worobey MichaelORCID, Schnalke ThomasORCID, Wolff ThorstenORCID, Lemey PhilippeORCID, Calvignac-Spencer SébastienORCID
Abstract
AbstractThe 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference55 articles.
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