Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation

Author:

Mälarstig AndersORCID,Grassmann Felix,Dahl LeoORCID,Dimitriou MariosORCID,McLeod Dianna,Gabrielson Marike,Smith-Byrne Karl,Thomas Cecilia E.ORCID,Huang Tzu-HsuanORCID,Forsberg Simon K. G.ORCID,Eriksson PerORCID,Ulfstedt Mikael,Johansson Mattias,Sokolov Aleksandr V.,Schiöth Helgi B.,Hall Per,Schwenk Jochen M.ORCID,Czene Kamila,Hedman Åsa K.ORCID

Abstract

AbstractBiomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association between protein levels, clinical characteristics, and gene variants, and to identify proteins with a causal role in breast cancer. We present 812 cis-acting protein quantitative trait loci for 737 proteins which are used as instruments in Mendelian randomisation analyses of breast cancer risk. Of those, we present five proteins (CD160, DNPH1, LAYN, LRRC37A2 and TLR1) that show a potential causal role in breast cancer risk with confirmatory results in independent cohorts. Our study suggests that these proteins should be further explored as biomarkers and potential drug targets in breast cancer.

Publisher

Springer Science and Business Media LLC

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