Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy-Reference-Cited by-同舟云学术

Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy

Published:2021-01-19 Issue:1 Volume:12 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Alteri Claudia^ORCID,Cento Valeria,Piralla Antonio^ORCID,Costabile Valentino^ORCID,Tallarita Monica,Colagrossi Luna,Renica Silvia,Giardina Federica,Novazzi Federica,Gaiarsa Stefano,Matarazzo Elisa,Antonello Maria,Vismara Chiara,Fumagalli Roberto,Epis Oscar Massimiliano,Puoti Massimo,Perno Carlo Federico^ORCID,Baldanti Fausto

Abstract

AbstractFrom February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy.

Funder

This work was financially supported by an unrestricted grant from Cariplo foundation.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-020-20688-x.pdf

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